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KMID : 0604520110370030275
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Journal of the Society of Cosmetic Scientists of Korea
2011 Volume.37 No. 3 p.275 ~ p.282
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Whitening Efficacy Study of Natural Compounds-Peptide Derivatives via cAMP Signaling Pathway
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Lee Hye-Suk
Shin Kyong-Hoon
Ryu Geun-Seok
Jee Kyung-Yup
Cho In-Sik
Kim Han-Young
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Abstract
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Novel whitening agents were prepared using peptide-Natural origin compound derivatives. The peptide could be an antagonist of MC1R and Natural origin compound were well-known material as a Tyrosinase inhibitor. We also suggest the new assay method which could evaluate the Antagonistic effectiveness to MC1R using cAMP signaling pathway. 24 candidates were synthesized and 11 peptide derivatives were selected by cAMP assay method. To evaluate cAMP assay, the selected peptide derivatives were assayed to evaluate their melanogensis inhibitory activity. At this work, we could know that the sequences which include -RW- have a melanogensis inhibitory activity, and cAMP assy could use as a evaluating method of MC1R antagonist. But, to evaluate the whitening activity of some material, cross-checking with melanin inhibitory assay method was recommended.
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KEYWORD
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α-MSH, MC1R, antagonist, cAMP, melanogenesis
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